Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity
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چکیده
منابع مشابه
Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity
Adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NAD) are released as danger signals from cells during infection and sterile inflammation. In the extracellular compartment ATP is converted by CD39, CD73, and other ecto-enzymes into metabolites that modulate the activity of T cells and macrophages. While ATP mediates pro-inflammatory signals via P2X7 and other P2 receptors, ad...
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1 Research Center for Ageing and Osteoporosis, Departments of Diagnostics and Medicine, Copenhagen University Hospital Glostrup, 2600 Glostrup, Denmark 2Department of Morphology, Surgery and Experimental Medicine, Section of General Pathology, University of Ferrara, 44121 Ferrara, Italy 3 Bone Biology Laboratory, Department of Cell and Developmental Biology, University College London, London WC...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2018
ISSN: 1663-9812
DOI: 10.3389/fphar.2018.00266